Lopirel Plus Tablet 10pcs

✔️ Uses of Lopirel Plus Tablet

Prevention of heart attack and stroke.

✔️ How does Lopirel Plus Tablet work?

Lopirel Plus Tablet combines Aspirin and Clopidogrel, serving as blood thinners (anti-platelet agents) that deter clot formation within blood vessels. The dual action of these components helps maintain unobstructed blood flow, preventing various cardiovascular complications.

Aspirin:

• Functions as a blood-thinning or anti-platelet agent at a low dose (typically 75 mg).
• Primarily aims to prevent heart attacks and strokes.

Clopidogrel:

• Targets the prevention of blood clots in conditions such as severe chest pain (unstable angina), heart attacks, strokes, and peripheral arterial disease.

✔️ Side Effects of Lopirel Plus Tablet

• Abdominal pain
• Indigestion
• Diarrhoea
• Easy bruising
• Nosebleeds
• Increased bleeding tendency

✔️ Quick Suggestions:

• Do not use other over-the-counter medications, herbal, or vitamin supplements without informing your pharmacist or doctor.
• Keep cholesterol and triglyceride levels under control through appropriate measures.
• Incorporate regular exercise into your routine to maintain heart health.
• Learn from your doctor how to recognize and manage early symptoms of heart disease.
• Inform your doctor if you have a scheduled surgery.
• This medicine may increase the risk of bleeding, and your doctor will guide managing this risk during surgical procedures.

✔️ Indications:

Aspirin+Clopidogrel is used to prevent Prevention of heart attack and stroke. It decreases the chances of having another heart attack or stroke from a disease related to your heart or blood vessels.

✔️ Pharmacology

Clopidogrel, the active ingredient, inhibits platelet activation and aggregation by binding irreversibly to platelet P2Y12 ADP receptors. A single oral dose can dosage-dependently inhibit platelet aggregation two hours later. Repeated doses of 75 mg per day lead to a stable antiplatelet effect between Days 3 and 7.

✔️ Dosage & Administration:

• For patients needing an antiplatelet effect within hours, start with a single 300 mg (4 tablets) oral loading dose, followed by 75 mg once daily.
• For recent MI, recent stroke, or established peripheral arterial disease: 75 mg once daily orally without a loading dose.
• It can be taken orally with or without food.

✔️ Interaction

Lopirel Plus Tablet may interact with various medications, including:

• Blood thinners (warfarin, heparin)
• Anti-psychotics (fluoxetine, lithium)
• Anti-diabetics (glibenclamide, repaglinide)
• Anti-cancer drugs (methotrexate)
• Gout medicines (probenecid)
• Anti-epilepsy drugs (valproate, phenytoin)
• Anti-inflammatory medication (ibuprofen)
• Drugs for upset stomach (omeprazole)
• Antifungals (fluconazole)
• HIV drugs (ritonavir, cobicistat)

It is crucial to inform your doctor about all medications you are taking to prevent potential interactions.

Drug-Food Interaction:

• Alcohol: Limit alcohol intake, as it may elevate blood pressure, increasing the risk of heart disease.
• Dietary Considerations: Avoid fatty foods, and maintain control over cholesterol and triglyceride levels.

Drug-Disease Interaction: Before taking Lopirel Plus Tablet, inform your doctor if you have a medical history of:

• Allergic reactions to medicines
• Heart diseases
• Active bleeding disorders
• Asthma
• Lopirel Plus Tablet in an artery of your brain (ischemic stroke)
• Liver and kidney diseases

✔️ Contraindications

Lopirel Plus Tablet is contraindicated in individuals with hypersensitivity to any component, the medication substance, or active pathological bleeding, such as cerebral hemorrhage or peptic ulcer.

✔️ Pregnancy & Lactation

• No well-controlled trials in pregnant women; use only if necessary.
• Not known to be excreted in human breast milk; a decision should be made whether to cease breastfeeding or the drug, considering its relevance to the mother.

✔️ Precautions & Warnings

• Genetic variants and drugs blocking CYP2C19 may interfere with metabolism.
• The risk of bleeding may increase; platelet transfusions may be less successful in restoring hemostasis.
• Discontinuation increases the risk of cardiovascular events.
• Reports of TTP require immediate medical attention.
• Increased risk of bleeding; caution with sharp objects.
• Temporary discontinuation may be required for surgeries or dental procedures.

✔️ Storage Conditions

Keep in a dry area below 30°C, away from light. Do not freeze. Keep out of children's reach.